Aggrecan Function



Aggrecan function



Kiani C, Chen L, Wu YJ, Yee AJ, Yang BB. Sunnybrook and Women's College Health Sciences Centre. Aggrecan also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1 is a protein that in humans is encoded by the ACAN gene. Aggrecan and Versican: Aggrecan, whose molecular mass is about 2500 kDa, is a typical. Cartilage contains a variety of proteoglycans that are essential for its normal function. 1. Link proteins have a structure analogous to that of the G1 region of aggrecan, possessing A, B1 and B2 domains and are thus members of the hyalectan family, the. Cell death and differentiation is a monthly research journal focused on the exciting field of programmed cell death and apoptosis.

PDF Version(364K) Cartilage: Aggrecan: Background to Aggregation: What Structures are Involved in Aggregation. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage. Wight, T N, Heinegard, D K, Hascall, V C: Proteoglycans: structure and function. aggrecan charge and hence function could be affected by size polymorphism within the CS1 domain, as those individuals with the shortest core protein length would Molecular function: Cellular component: Biological process: Sources:. In this way aggrecan plays a crucial role in the normal function of articular cartilage, which is found at the ends of long bones.

Aggrecan degradation



Aggrecanase and aggrecan degradation in osteoarthritis: a review. Inhibition of ADAM-TS4 and ADAM-TS5 Prevents Aggrecan Degradation in Osteoarthritic Cartilage* Received for publication, January 15, 2002, and in revised form, April. Degradation of the large cartilage proteoglycan aggrecan in. Read by researchers in: 78% Biological Sciences, 11% Medicine. Collagen and Aggrecan Degradation Is Blocked in Interleukin-1-Treated Cartilage Explants by an Inhibitor of I?B Kinase through Suppression of. Aggrecan is a critical component for cartilage structure and the function of joints. The synthesis and degradation of aggrecan are being investigated for their roles in.

Munteanu SE, Ilic MZ, Handley CJ: Highly sulfated glycosaminoglycans inhibit aggrecanase degradation of aggrecan by bovine articular cartilage explant. Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5. The synthesis and degradation of aggrecan are being investigated for their roles in cartilage deterioration during joint injury, disease, and aging. 1. Aggrecan degradation was monitored by assessing sulfated glycosaminoglycan released into the media using the dimethylmethylene. In healthy cartilage, there is some synthesis and degradation of type II collagen as well as the proteoglycan aggrecan.

Aggrecan aggregate



The material with the highest density is termed A1 and it is this which contains the aggrecan. Imbalances in aggrecan or link protein concentrations, or degradation of HA, disrupted the network and caused the chondrocytes to aggregate or adhere to the plates 16, 17. up to ?100 aggrecan monomers to form the aggrecan aggregate.

Loss of cartilage integrity in arthritis is associated with. In addition, HA binds to the surface of many cells by the CD44 cell receptor; this HA binding can inhibit. The proteoglycan aggregate is a major component of the articular cartilage extracellular matrix comprising hyaluronan (HA), aggrecan, and link protein. Aggrecan also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1 is a protein that in humans is encoded by the ACAN gene.




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